Gonadorelin (2mg)
Gonadorelin, also known as GnRH (Gonadotropin-Releasing Hormone) or LHRH (Luteinizing Hormone-Releasing Hormone), is a synthetic decapeptide analog of the naturally occurring hypothalamic hormone that regulates reproductive function. It acts as the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis, controlling the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. Gonadorelin is extensively used in research to study reproductive endocrinology, fertility mechanisms, and hormonal regulation.
- •Direct stimulation of LH and FSH release from the pituitary gland
- •Restoration of natural pulsatile gonadotropin secretion patterns
- •Support for testicular and ovarian function through upstream hormonal signaling
- •Valuable tool for assessing pituitary gonadotroph responsiveness
- •Research applications in fertility, hypogonadism, and reproductive aging
Gonadorelin binds to GnRH receptors (GnRHR) on gonadotroph cells in the anterior pituitary gland. This binding activates G-protein coupled receptor signaling pathways, primarily through Gq/11 proteins, which stimulate phospholipase C (PLC) activity. The resulting increase in inositol triphosphate (IP3) and diacylglycerol (DAG) leads to elevated intracellular calcium levels and activation of protein kinase C (PKC). These signaling cascades trigger the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) into the bloodstream. LH and FSH then act on the gonads (testes in males, ovaries in females) to stimulate sex hormone production (testosterone, estradiol) and support gametogenesis (sperm production, follicle development). The pulsatile nature of gonadorelin administration is critical, as continuous exposure leads to receptor desensitization and paradoxical suppression of gonadotropin release—a principle exploited therapeutically in GnRH agonist treatments for hormone-dependent conditions.
Gonadorelin is used in reproductive endocrinology research to investigate the regulation of the HPG axis, including studies on pulsatile hormone secretion, feedback mechanisms, and age-related changes in reproductive function. It serves as a diagnostic tool in pituitary function testing to assess gonadotroph reserve and responsiveness. Research applications include fertility studies examining ovulation induction, spermatogenesis support, and hypogonadotropic hypogonadism. Gonadorelin is also valuable in studying the effects of hormonal restoration on metabolic parameters, body composition, and overall endocrine health in research models with impaired HPG axis function.
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.