KPV
Anti-inflammatory tripeptide for gut health and immune research.
KPV is a tripeptide (lysine-proline-valine) derived from the C-terminal end of alpha-melanocyte stimulating hormone (α-MSH). This small peptide demonstrates potent anti-inflammatory and antimicrobial properties, making it a valuable tool for investigating immune modulation and mucosal barrier function. KPV lacks melanocortin receptor binding activity, exerting its effects through alternative, melanocortin-independent signaling pathways.
- •Potent anti-inflammatory activity without broad immunosuppression.
- •Inhibits key inflammatory signaling pathways, including NF-κB.
- •Demonstrates antimicrobial properties against various pathogens.
- •Supports mucosal barrier integrity and intestinal health research.
- •Reduces pro-inflammatory cytokine production (e.g., TNF-α, IL-6).
- •Promotes tissue repair and accelerates wound healing models.
- •Exhibits stability suitable for gastrointestinal and topical delivery research.
KPV exerts its anti-inflammatory effects primarily by directly interfering with intracellular inflammatory signaling cascades, distinct from canonical melanocortin receptor activation. The peptide effectively inhibits the activation and nuclear translocation of NF-κB (nuclear factor kappa B), a master regulator of inflammatory gene expression. By blocking NF-κB, KPV significantly reduces the transcription of major pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β. Furthermore, KPV modulates MAPK signaling pathways involved in cellular stress and inflammation. Beyond inflammation control, KPV supports mucosal barrier function by promoting the expression of tight junction proteins, thereby reducing intestinal permeability. Its anti-inflammatory action is notable for reducing pathological inflammation while preserving normal immune function. The peptide also exhibits antimicrobial activity through direct interaction with bacterial cell membranes and contributes to cellular defense mechanisms via antioxidant properties.
KPV is extensively utilized in research models focusing on chronic inflammatory conditions, particularly inflammatory bowel disease (Crohn's disease and ulcerative colitis) and various dermatological disorders. Its unique combination of properties makes it ideal for investigating mucosal barrier function, intestinal permeability, and targeted anti-inflammatory interventions affecting epithelial surfaces. Specific research applications include studies on wound healing and tissue repair mechanisms, investigations into melanocortin-independent anti-inflammatory pathways, and comparative analyses with other immunomodulatory agents. KPV is also employed in mechanism studies targeting NF-κB signaling, antimicrobial peptide development, and the formulation of novel oral or topical delivery systems for localized inflammation management.
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.