SLU-PP-332
SLU-PP-332 is a novel research compound functioning as a selective agonist for Estrogen-Related Receptor alpha (ERR$\alpha$). This orphan nuclear receptor is critical for regulating mitochondrial biogenesis, oxidative metabolism, and energy homeostasis, independent of traditional estrogen signaling. SLU-PP-332 provides a powerful tool for investigating metabolic efficiency, mitochondrial function, and exercise mimetics.
- •Selective ERR$\alpha$ agonism for targeted metabolic research.
- •Enhances mitochondrial biogenesis and oxidative capacity.
- •Promotes oxidative metabolism and fatty acid utilization.
- •Valuable for studies examining exercise mimetics and endurance enhancement.
- •Supports research into metabolic disorders and mitochondrial dysfunction.
- •Facilitates investigation of muscle fiber type adaptation and energy homeostasis.
- •Provides insights into orphan nuclear receptor pharmacology and signaling.
SLU-PP-332 acts by selectively binding to ERR$\alpha$, an orphan nuclear receptor that regulates genes essential for energy production and oxidative metabolism. Upon binding, SLU-PP-332 enhances the receptor's transcriptional activity at ERR response elements (ERREs), promoting the expression of genes encoding mitochondrial proteins, oxidative phosphorylation components, and fatty acid oxidation enzymes. This agonism leads to a significant upregulation of PGC-1$\alpha$ (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), which is the master regulator of mitochondrial biogenesis, thereby amplifying cellular mitochondrial adaptation. The resulting increase in mitochondrial density and function boosts the capacity for cellular ATP production and supports a shift toward more oxidative muscle fiber types. Unlike compounds targeting energy sensors like AMPK, SLU-PP-332 provides a unique, direct mechanism for enhancing metabolic efficiency and oxidative capacity through specific nuclear receptor activation.
SLU-PP-332 is primarily utilized in research focused on exercise mimetics and endurance enhancement, given its potent effects on mitochondrial function and oxidative capacity. It is critical for investigations into metabolic disorders, including models of insulin resistance, where enhanced oxidative metabolism is desired. Further applications include detailed studies of mitochondrial biogenesis and dysfunction, research into muscle fiber type adaptation, and the pharmacological characterization of ERR$\alpha$ signaling pathways. The compound is also valuable for comparative studies with other metabolic modulators and for advancing the understanding of orphan nuclear receptor-targeted therapeutic strategies.
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.