MOTS-C
Mitochondrial-derived peptide for metabolic health
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a novel mitochondrial-derived peptide (MDP) encoded by mitochondrial DNA. It functions as a critical signaling molecule involved in regulating systemic metabolic homeostasis.
- •Investigating metabolic regulation and energy expenditure.
- •Studying improvements in peripheral insulin sensitivity.
- •Modeling enhanced physical endurance and exercise capacity.
- •Exploring mechanisms of cellular longevity and aging.
- •Analyzing mitochondrial communication and signaling pathways.
- •Researching novel approaches to glucose uptake and utilization.
MOTS-c primarily targets skeletal muscle, where it promotes glucose metabolism by inhibiting the folate cycle and suppressing the activity of AICAR transformylase (ATIC). This modulation leads to the activation of the AMPK pathway, subsequently enhancing glucose uptake independently of insulin signaling. By influencing these fundamental metabolic processes, MOTS-c acts as an endocrine factor linking mitochondrial function to whole-body energy balance. Furthermore, MOTS-c has been shown to translocate to the nucleus under certain conditions, suggesting potential roles in gene expression regulation related to stress response and cellular defense mechanisms. Its function as a peptide hormone underscores its broad influence on cellular energy dynamics and systemic metabolic control.
MOTS-c is highly valuable for studies focused on metabolic disorders, particularly Type 2 Diabetes and insulin resistance, due to its potent effects on glucose homeostasis. Researchers utilize this peptide to explore therapeutic strategies aimed at improving peripheral insulin sensitivity and mitigating symptoms of metabolic syndrome. Beyond metabolism, MOTS-c serves as a crucial tool in gerontology research, enabling the investigation of mitochondrial signaling pathways linked to lifespan extension and the maintenance of cellular health during aging. Its role in enhancing physical performance also makes it relevant for exercise physiology and the study of muscle adaptation.
Based on research applications and synergistic mechanisms, this peptide is frequently combined with:
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.