SS-31
Mitochondrial-targeting peptide (Elamipretide)
SS-31 (Elamipretide) is a synthetic, mitochondria-targeting tetrapeptide designed to selectively localize within the inner mitochondrial membrane. This compound is utilized in research to investigate mitochondrial stabilization and bioenergetic improvement. It represents a critical tool for studying cellular energy regulation under stress conditions.
- •Stabilizes cardiolipin structure within the inner mitochondrial membrane.
- •Enhances overall mitochondrial respiratory function.
- •Investigates protection against ischemia-reperfusion injury (IRI).
- •Models mitigation of age-related cellular energy deficits.
- •Supports research into mitochondrial dysfunction pathology.
- •Offers high selectivity for mitochondrial localization.
SS-31 functions by crossing the mitochondrial outer membrane and concentrating specifically within the inner mitochondrial membrane (IMM). Its primary mechanism involves binding directly to cardiolipin, a critical phospholipid essential for maintaining the structure and function of the electron transport chain complexes. By stabilizing cardiolipin, SS-31 effectively preserves the integrity of the IMM, which is crucial for maintaining the proton gradient necessary for ATP synthesis. This stabilization prevents the oxidative damage and subsequent peroxidation of cardiolipin often observed during periods of cellular stress, such as oxidative stress or ischemia. By maintaining IMM integrity and optimizing the environment for respiratory chain components, SS-31 ensures efficient electron flow and improved mitochondrial bioenergetics.
The primary research applications for SS-31 revolve around models of cellular energy impairment and oxidative stress. It is extensively used to study mitochondrial dysfunction across various disease states, including neurodegenerative disorders where mitochondrial integrity is compromised. Furthermore, SS-31 is a valuable agent for investigating therapeutic strategies against ischemia-reperfusion injury, particularly in cardiac and renal models, where its ability to protect mitochondria during the reperfusion phase is critical. Its role in mitigating age-related decline in cellular energy production also positions it as a key compound in geroscience research focused on maintaining cellular vitality and metabolic health.
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.